Related Experiment Video
Updated: May 23, 2026
Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model
Published on: August 13, 2017
Biological response to porcine xenograft implants: an experimental study in rabbits
José Luis Calvo-Guirado1, Gerardo Gómez-Moreno, Javier Guardia
1General Dentistry, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain. josecalvog@gmail.com
Purpose:
The aim of this study was to evaluate the effect of a new porcine biomaterial and collagen paste in 20 New Zealand rabbits.
Materials And Methods:
Forty implants using a porcine xenograft made up of 80% corticocancellous collagenated bone particles of ≤300 μm in size were placed in the proximal metaphyseal area of both tibiae. Four periods of time were formed: 1h, 5, 8, and 15 months. After implantation, an anteroposterior and lateral radiological study was carried out. Samples were sectioned at 5 μm and stained using hematoxylin-eosin, Masson's trichromic, and Gordon-Switt reticulin stains.
Results:
These results confirmed the biocompatibility of this porcine biomaterial-collagen paste; only a few, occasional macrophages and scattered lymphocytes were observed. No fibrosis was observed between the implants and the bone. Moreover, the material was osteoconductive acting as a "scaffold" for bone cells, and there was a progressive increase in bone growth in and around the implants.
Conclusion:
This new porcine biomaterial-collagen paste seemed to be biocompatible, bioresorbable, and osteoconductive.
