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Published on: February 23, 2014
Pneumococcal infections: association with asthma and COPD
1Service de pneumologie, hôpital Cochin, AP-HP, université Paris-Descartes, Sorbonne Paris Cité, 27, rue du Faubourg St-Jacques, 75014 Paris, France.
Asthma doubles the risk of pneumococcal infections like pneumonia, despite not being a current vaccination indication. Further research is needed to confirm the effectiveness of new vaccines for asthma patients.
Area of Science:
- Infectious Diseases
- Pulmonology
- Vaccinology
Background:
- Pneumococci cause severe respiratory and invasive infections.
- Pneumococcal vaccination is recommended for high-risk adults.
- Asthma is not a current indication for pneumococcal vaccination.
Purpose of the Study:
- To evaluate the association between asthma and pneumococcal infections.
- To explore the potential role of pneumococcal vaccination in asthma patients.
Main Methods:
- Review of recent epidemiological studies on asthma and pneumococcal infections.
- Analysis of biological data regarding pneumococcal susceptibility in asthmatics.
Main Results:
- Asthma is associated with a doubled risk of pneumonia and invasive pneumococcal infections.
- Pneumococci contribute to acute exacerbations and pneumonia in COPD patients.
- Current pneumococcal vaccines have not demonstrated decreased mortality in COPD patients.
Conclusions:
- Asthma may increase susceptibility to pneumococcal infections.
- Pneumococcal conjugate vaccines warrant further investigation for asthma patients.
- Clinical and cost-effectiveness of new vaccines in asthma requires demonstration.
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