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Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood

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Association analysis between pseudorabies antibody and five single-nucleotide polymorphisms in pigs.

S J Zhang¹, O Jafer, J F Yuan

¹1Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, HuaZhong Agricultural University, 430070, China.

Animal : an International Journal of Animal Bioscience

|March 27, 2012

Summary

Researchers identified a specific gene variant (SNP in EHMT2) associated with higher pseudorabies virus (PrV) antibody levels in pigs. This finding could help identify animals resistant or susceptible to PrV, aiding disease management in swine production.

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Area of Science:

Veterinary Genetics
Animal Immunology
Swine Disease Research

Background:

Pseudorabies virus (PrV) causes significant economic losses in global pig production due to reproductive issues and high neonatal mortality.
Genetic factors, specifically single-nucleotide polymorphisms (SNPs) in candidate genes, may influence pig susceptibility or resistance to PrV infection.
No prior studies have investigated associations between host candidate genes and PrV phenotypic traits.

Purpose of the Study:

To identify host genes contributing to PrV phenotypes through association studies.
To investigate the relationship between specific SNPs in candidate genes and PrV antibody levels in pigs.

Main Methods:

Genotyping of five SNPs in four candidate genes (IL10, CXCL12, BAT2, EHMT2) in 178 sows using high-throughput microarray technology.
Quantification of PrV antibodies via enzyme-linked immunosorbent assay (ELISA).
Statistical analysis (ANOVA, Duncan method) using SAS software to assess associations between SNP genotypes and antibody levels.

Main Results:

A significant association was found between a specific SNP (EHMT2-SNP2) and PrV glycoprotein E-ELISA antibody levels.
Pigs with EHMT2-SNP2 genotypes 11(AA) and 12(AG) exhibited significantly higher antibody levels compared to pigs with genotype 22(GG) (P < 0.05).

Conclusions:

The identified SNP in the EHMT2 gene is a potential genetic marker for predicting susceptibility or resistance to PrV.
This genetic marker can be a valuable tool for selecting resistant animals in conjunction with traditional breeding methods to mitigate PrV impact in the pig industry.