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Related Concept Videos

Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.

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Related Experiment Video

Updated: May 23, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

Using Tablet for visual exploration of second-generation sequencing data.

Iain Milne1, Gordon Stephen, Micha Bayer

  • 1Information & Computational Sciences, The James Hutton Institute JHI, Dundee DD2 5DA, Scotland, UK. iain.milne@hutton.ac.uk

Briefings in Bioinformatics
|March 27, 2012
PubMed
Summary
This summary is machine-generated.

Tablet is a high-performance viewer for visualizing second-generation sequencing (2GS) data, addressing challenges like large data volumes and short reads. It aids in quality assurance and scientific discovery for genomic sequence assemblies.

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Related Experiment Videos

Last Updated: May 23, 2026

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Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

Area of Science:

  • Bioinformatics
  • Genomics
  • Computational Biology

Background:

  • Second-generation sequencing (2GS) technologies generate vast amounts of data, presenting significant visualization challenges.
  • Existing tools struggle with the scale, short read lengths, and diverse data formats inherent in modern sequencing.
  • Effective visualization is crucial for analyzing 2GS data, ensuring quality, and driving scientific discovery.

Purpose of the Study:

  • To present Tablet, a high-performance graphical viewer designed for second-generation sequencing assemblies and read mappings.
  • To demonstrate Tablet's utility in quality assurance and scientific discovery through practical use cases.
  • To explain the computational and visualization techniques enabling Tablet's responsive and versatile graphical environment.

Main Methods:

  • Development of Tablet, a graphical viewer optimized for large-scale genomic data.
  • Implementation of features including whole-reference coverage overviews, variant highlighting, and paired-end read markup.
  • Integration of GFF3-based feature tracks and protein translations for comprehensive analysis.
  • Utilization of advanced computing and visualization techniques for a responsive user experience.

Main Results:

  • Tablet effectively visualizes large volumes of 2GS data, accommodating diverse data types and formats.
  • Demonstrated value in quality assurance through features like variant highlighting and coverage visualization.
  • Facilitated scientific discovery by enabling easy examination of sequence assemblies and read mappings.

Conclusions:

  • Tablet is a valuable tool for the analysis of second-generation sequencing data.
  • Its high-performance graphical environment simplifies the visualization of complex sequence assemblies and read mappings.
  • Tablet supports quality assurance and scientific discovery in genomics research.