Left ventricular diastolic dysfunction in patients with metabolic syndrome
Davor Penjasković1, Dejan Sakac, Jovanka Dejanović
1General Hospital Sremska Mitrovica. drpenjaskovic@gmail.com
Medicinski Pregled
|March 29, 2012
Summary
Metabolic syndrome is linked to diastolic dysfunction. The severity of diastolic dysfunction increases with more metabolic syndrome characteristics, particularly hypertension, obesity, hyperglycemia, and high triglycerides.
Area of Science:
- Cardiology
- Metabolic Disorders
- Echocardiography
Background:
- Metabolic syndrome (MetS) is a prevalent condition associated with increased cardiovascular risks.
- Diastolic dysfunction is a key indicator of cardiac health, often preceding heart failure.
Purpose of the Study:
- To investigate the association between metabolic syndrome components and the grade of diastolic dysfunction.
- To determine if the number of MetS criteria correlates with diastolic dysfunction severity.
Main Methods:
- Echocardiography was used to assess diastolic function in 72 patients meeting MetS criteria (IDF).
- Exclusion criteria included age >65, impaired systolic function, atrial fibrillation, and valvular/pericardial disease.
Main Results:
- A significant positive correlation was observed between the number of MetS characteristics and diastolic dysfunction grade (p < 0.0001).
- Waist circumference, arterial hypertension, impaired glucose tolerance/diabetes, and hypertriglyceridemia showed significant positive correlations with diastolic dysfunction grade.
- Low high-density lipoprotein levels did not correlate significantly with diastolic dysfunction.
Conclusions:
- Metabolic syndrome is associated with diastolic dysfunction.
- The grade of diastolic dysfunction is dependent on the number of coexisting metabolic syndrome characteristics.
- Arterial hypertension, central obesity, hyperglycemia, and hypertriglyceridemia are key factors correlating with diastolic dysfunction severity.
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