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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
[Acute pancreatitis in children]
Radoica Jokić1, Pavle Milosević
1Institut za zdravstvenu zastitu dece i omladine Vojvodine, Novi Sad. jokic_rs@eunet.yu
Insights
Acute pancreatitis in children, often caused by trauma or biliary issues, requires prompt diagnosis and management. Treatment involves medication to reduce pancreatic activity, with surgery reserved for severe cases.
Area of Science:
- Pediatric Gastroenterology
- Pancreatic Diseases
Context:
- Acute pancreatitis in children presents unique challenges.
- Etiologies include abdominal trauma, biliary-pancreatic anomalies, and other diseases.
- Disruption of exocrine and endocrine pancreatic functions can occur.
Purpose:
- To outline the diagnostic and therapeutic strategies for acute pancreatitis in pediatric patients.
- To emphasize the importance of clinical experience and a rational approach.
Summary:
- Clinical findings include abdominal pain, gastrointestinal distress, and general deterioration.
- Diagnostic tools comprise blood/urine tests (amylase, CRP, electrolytes) and imaging (ultrasound, CT, endoscopy).
- Initial management focuses on non-operative treatment with medications to control pain and pancreatic activity; surgery is indicated if conservative measures fail.
Impact:
- Highlights the serious nature of pediatric acute pancreatitis.
- Stresses the need for accurate diagnosis and tailored treatment plans.
- Informs clinical practice for managing this critical condition in children.
Introduction:
Acute pancreatitis in children is mostly due to abdominal trauma, diseases or congenital anomalies of the biliary-pancreatic tree. Both exogenous and endogenous functions of the gland could be disturbed by various levels of damage. CLINICAL FINDING AND DIAGNOSTICS: Acute abdominal pain, gastrointestinal signs and general deterioration are the main clinical findings. The examination can be completed by blood and urine tests of amylase, electrolytes level, and the C-reactive protein. In addition to these tests, ultrasound, computed tomography and endoscopy are required as well.
Therapeutic Methods:
The therapy of choice is non-operative treatment using medicaments to control the pain, decrease the pancreatic activity and prevent further complications. If the conservative treatment fails, the surgical approach is necessary: drainage, resections, by-pass procedures, etc.
Conclusion:
Acute pancreatitis is a very serious disease in childhood. Clinical experience and rational approach are very important in the diagnostic and therapeutic methods.
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