Obesity is not associated with increased mortality and morbidity in critically ill children

Vi Lier Goh1, Martin K Wakeham, Ruta Brazauskas

  • 1Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.

Insights

Critically ill children who are overweight or obese and require mechanical ventilation do not have increased mortality or longer hospital stays. Obesity does not appear to negatively impact outcomes for these pediatric patients.

Area of Science:

  • Pediatric critical care medicine
  • Pediatric intensive care
  • Obesity research

Background:

  • Childhood obesity is a growing concern with potential health implications.
  • The impact of obesity on outcomes for critically ill children requiring mechanical ventilation is not well-established.

Purpose of the Study:

  • To investigate the association between obesity and outcomes in critically ill children requiring invasive mechanical ventilation.
  • To compare mortality, duration of mechanical ventilation, and length of stay (LOS) in pediatric intensive care units (PICUs) among children with varying weight categories.

Main Methods:

  • Retrospective cohort study of 1030 children (2-18 years) admitted to a PICU requiring invasive ventilation between 2005-2009.
  • Patients categorized by weight z-score: normal, overweight, obese, and severely obese. Underweight patients excluded.
  • Outcomes analyzed: mortality, ventilator days, and PICU LOS using univariate and multivariate regression analyses.

Main Results:

  • No significant difference in risk-adjusted mortality rates between normal-weight, overweight, obese, and severely obese children.
  • Total mechanical ventilation days and PICU length of stay were similar across all weight categories after adjusting for risk factors.

Conclusions:

  • Overweight, obese, and severely obese children requiring invasive mechanical ventilation in the PICU experience similar mortality and resource utilization compared to normal-weight children.
  • Obesity status does not appear to be an independent risk factor for adverse outcomes in this critically ill pediatric population.
Abstract

Related Concept Videos

Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
Bulimia Nervosa01:30

Bulimia Nervosa

Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
Anorexia Nervosa01:28

Anorexia Nervosa

Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...