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Related Experiment Video

Updated: May 23, 2026

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
08:26

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles

Published on: October 19, 2015

Highly sensitive magnetite nano clusters for MR cell imaging.

Mingli Li1, Hongchen Gu, Chunfu Zhang

  • 1School of Biomedical Engineering & Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China. cfzhang@sjtu.edu.cn.

Nanoscale Research Letters
|April 3, 2012
PubMed
Summary

Highly sensitive magnetite nanoclusters (MNCs) show promise for cell imaging. These iron oxide nanoparticles exhibit excellent MR sensitivity and no adverse cellular effects, outperforming commercial agents for MR cell tracking.

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • High sensitivity and controllable size are critical for magnetic iron oxide contrast agents used in cell imaging.
  • Existing contrast agents face limitations in sensitivity and optimal size for effective cellular visualization.

Purpose of the Study:

  • To fabricate highly MR-sensitive magnetite nanoclusters (MNCs) with tunable sizes for enhanced cell imaging.
  • To evaluate the MR sensitivity, cellular toxicity, and imaging efficiency of the developed MNCs compared to commercial agents.

Main Methods:

  • Fabrication of magnetite nanoclusters (MNCs) with controlled sizes.
  • Assessment of transverse relaxivity (r2) in water suspensions.
  • In vitro and in vivo cell labeling and imaging using RAW 264.7 cells.

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  • Comparison with a commercial contrast agent (SHU555A/Resovist).

    • Main Results:

    • Fabricated MNCs exhibited tunable sizes and high MR sensitivity.
    • MNCs with an average size of 63 nm achieved a transverse relaxivity of 630 s-1mM-1, among the highest reported for iron oxide agents.
    • The MNCs demonstrated no adverse effects on RAW 264.7 cells.
    • In vitro and in vivo cell imaging showed significantly higher efficiency and sensitivity compared to Resovist, with detection limits of 3,000 and 10,000 cells, respectively.

    Conclusions:

    • The developed magnetite nanoclusters are highly sensitive and safe for cell imaging applications.
    • These MNCs offer superior performance over existing commercial agents for both in vitro and in vivo MR cell tracking.
    • The study highlights the potential of these MNCs as promising contrast agents for clinical MR cell tracking.