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Related Experiment Video

Updated: May 23, 2026

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

Published on: May 19, 2016

Surgery for psychiatric disorders.

Judy Luigjes¹, Bart P de Kwaasteniet, Pelle P de Koning

¹Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

World Neurosurgery

|April 3, 2012

Summary

This summary is machine-generated.

Deep brain stimulation (DBS) offers a promising surgical option for psychiatric disorders like obsessive-compulsive disorder, depression, addiction, and Tourette syndrome, with a 54% response rate in OCD. Further research is needed to optimize targets and increase controlled trials.

Keywords:

ALIC AN Addiction Anorexia nervosa Anterior limb of the internal capsule Circuits connecting orbitofrontal cortex DBS DDS Deep brain stimulation Dopamine dysregulation syndrome GPi Globus pallidus HDRS Hamilton Depression Rating Scale IPG ITP Inferior thalamic peduncle Internal pulse generator MDD Major depressive disorder Medial prefrontal cortex NAc Nucleus accumbens OCD OFC Obsessive-compulsive disorder Orbitofrontal cortex PG Pathologic gambling Psychosurgery SCG STN Subcallosal cingulate gyrus Subthalamic nucleus TRD TS Therapy-resistant depression Tourette syndrome VC/VS Ventral capsule/ventral striatum Y-BOCS Yale-Brown obsessive-compulsive scale mPFC

Related Experiment Videos

Last Updated: May 23, 2026

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

Published on: May 19, 2016

Area of Science:

Neurosurgery
Psychiatry
Neurology

Background:

Deep brain stimulation (DBS) is a reversible neurosurgical technique involving implanted electrodes to modulate brain activity.
It has resurged as a therapeutic option for specific psychiatric disorders.
DBS offers adjustable electrical stimulation to targeted brain regions.

Observation:

DBS shows promise for therapy-refractory obsessive-compulsive disorder (OCD), with reported response rates around 54% in trials.
Open trials indicate encouraging outcomes for DBS in treating therapy-refractory depression.
Case reports suggest potential benefits of DBS for addiction and Tourette syndrome.

Findings:

Controlled trials demonstrate the efficacy of DBS in specific psychiatric conditions.
Evidence from case series and trials supports DBS for Tourette syndrome.
DBS is an adjustable and reversible intervention for neurological and psychiatric conditions.

Implications:

Optimizing DBS target locations and increasing the number of controlled, double-blinded trials are crucial for advancing its clinical application.
Exploring novel indications and brain targets for DBS through preclinical research is warranted.
DBS represents a significant advancement in the surgical management of complex psychiatric disorders.