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Related Concept Videos

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model01:09

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model

Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the concentration...
Factors Influencing Drug Absorption: Drug Dissolution01:27

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The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH01:21

Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH

Drug absorption within the gastrointestinal (GI) tract is a complex process influenced by several critical factors, including the site pH, the drug's dissociation constant (pKa), and the drug's lipophilicity. The GI tract exhibits a pH gradient, with an acidic environment in the stomach and a more alkaline environment in the small intestine. This pH variation directly affects the ionization state of drugs.
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles in drug...
Bioavailability Enhancement: Drug Permeability Enhancement01:27

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After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Theories of Dissolution: Diffusion Layer Model01:15

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Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
18:57

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Published on: October 17, 2013

Predicting the solubility-permeability interplay when using cyclodextrins in solubility-enabling formulations: model

Jonathan M Miller1, Arik Dahan

  • 1Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.

International Journal of Pharmaceutics
|April 3, 2012
PubMed
Summary
This summary is machine-generated.

This study validates a mathematical model predicting drug permeability changes with cyclodextrins. The model accurately forecasts how hydroxypropyl-β-cyclodextrin (HPβCD) affects drug absorption, optimizing formulation strategies.

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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
05:08

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery
  • Physical Chemistry

Background:

  • Cyclodextrins enhance drug solubility but can reduce drug permeability.
  • Understanding the solubility-permeability interplay is crucial for drug formulation.
  • Mathematical modeling offers a quantitative approach to predict these effects.

Purpose of the Study:

  • To validate a previously developed mathematical mass transport model.
  • To assess the model's predictive capability using literature data for carbamazepine and hydrocortisone.
  • To confirm the model's accuracy in predicting drug permeability influenced by cyclodextrin complexation.

Main Methods:

  • Application of a mathematical mass transport model to predict drug permeability.
  • Testing the model with literature data for carbamazepine and hydrocortisone.
  • Comparing predicted effective permeability (P(eff)) with experimental values across varying HPβCD concentrations.

Main Results:

  • The mathematical model accurately predicted the effective permeability (P(eff)) for carbamazepine and hydrocortisone.
  • Excellent agreement was observed between predicted and experimental P(eff) values at all tested HPβCD concentrations.
  • The model successfully quantified the impact of molecular complexation on intestinal drug permeability.

Conclusions:

  • The validated mathematical model effectively predicts drug permeability changes due to cyclodextrins.
  • This model facilitates a more informed and efficient use of molecular complexation in drug formulation.
  • It enables formulators to optimize the solubility-permeability balance for enhanced oral drug absorption.