Related Experiment Video
Updated: May 23, 2026

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain
Published on: November 18, 2013
Age-related cognitive decline: can neural stem cells help us?
Benedetta Artegiani1, Federico Calegari
1DFG-Research Center and Cluster of Excellence for Regenerative Therapies Dresden, Technische Universität Dresden, Germany.
Boosting adult neurogenesis aids emotional behavior and cognitive functions like memory. This review explores strategies to enhance neurogenesis in aging brains for therapeutic benefits.
Area of Science:
- Neuroscience
- Gerontology
- Regenerative Medicine
Background:
- Adult neurogenesis positively impacts emotional behavior and cognitive functions.
- Aging negatively affects neural stem cell proliferation, contributing to cognitive decline.
- Research is exploring methods to boost neurogenesis in aged individuals.
Purpose of the Study:
- To review aging-induced changes impacting the neurogenic niche.
- To discuss strategies for increasing neurogenesis in the aged brain.
- To explore therapeutic potential for age-related cognitive decline.
Main Methods:
- Review of systemic, cellular, and molecular changes associated with aging.
- Analysis of factors affecting neural stem cell proliferation and fate.
- Examination of neuronal survival and integration in aged neurogenic niches.
Main Results:
- Aging induces detrimental changes in the neurogenic niche.
- Specific manipulations can increase neurogenesis in senescent animals.
- Enhanced neurogenesis shows promise for mitigating age-related cognitive deficits.
Conclusions:
- Targeting the neurogenic niche offers a potential therapeutic strategy for cognitive aging.
- Further research into enhancing neurogenesis could lead to treatments for age-related cognitive decline.
- Understanding aging's impact on neurogenesis is crucial for developing effective interventions.
More Related Videos
09:27Cell Sorting of Neural Stem and Progenitor Cells from the Adult Mouse Subventricular Zone and Live-imaging of their Cell Cycle Dynamics
Published on: September 14, 2015
06:52The "Brain Milking" Method for the Isolation of Neural Stem Cells and Oligodendrocyte Progenitor Cells from Live Rats
Published on: February 9, 2024
Related Concept Videos
Neurogenesis and Regeneration of Nervous Tissue
Stem Cell Culture
iPS Cell Differentiation
Stem Cell Therapy for Tissue Regeneration
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Multipotency of Hematopoietic Stem Cells