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Updated: May 23, 2026

The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
Published on: November 19, 2008
[Immune system disorders and their correction in critically ill patients with toxic and hypoxic encephalopathy]
A Loladze1, V Shilov, B Batotsyrenov
1Djanelidze Research Institute of Emergency medicine, Saint-Petersburg, Russia.
Abstract:
In this article there are materials, which were received in the process of treatment of 69 patients with azaleptin (leponeks) acute severe poisonings. The immunologic research has shown that the first phase of acute poisonings in patients with toxicohypoxic encephalopathy is accompanied by severe immune alterations. The alterations of proinflammation and antiinflammation cytokines have been investigated and its increase has not been revealed. It was shown, that the employment of citoflavin in intensive therapy of acute poisonings leads to decrease of the level of immunosupression.
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