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Updated: May 23, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
Synthesis of oxovanadium complexes and their apoptosis-inducing activity in leukemia cells
Tomoko Yamaguchi1, Shinya Watanabe, Yuriko Matsumura
1Department of Materials and Life Science, Faculty of Science and Technology, Seikei University, 3–3–1 Kichijojikitamachi, Musashino, Tokyo.
Abstract:
Vanadium complexes with different ligands were synthesized and evaluated for antiproliferative activity on U937 cells. The alkyl chain length of the ligands affected the antiproliferative activity, and two complexes-3b and 4-exhibited strong activities with IC(50) values of 6.02 and 3.90 μM respectively. Annexin V staining and DNA ladder formation indicated that these complexes induced apoptosis in U937 cells.
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