Related Experiment Video
Updated: May 23, 2026

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
Biological plaque control: novel therapeutic approach to periodontal disease
1Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan. sugano-n@dent.nihon-u.ac.jp
Abstract:
Despite its important role in the control of periodontal disease, mechanical plaque control is not properly practiced by most individuals. Therefore, adjunctive chemical plaque control using chlorhexidine and antibiotics has also been suggested as an additional therapeutic strategy to augment mechanical plaque control. However, the additional effects of adjunctive antibiotic therapy are small, and topical chlorhexidine therapy is not without side effects. Given current limitations, new approaches for the control of biofilm are required. The new therapeutic approaches discussed in this review are divided into two categories: probiotics and vaccines. Probiotics is an interesting new field of periodontology research that aims to achieve biological plaque control by eliminating pathogenic bacteria. In addition, passive immunization using egg yolk antibody raised against periodontal pathogens may be an effective approach for the treatment of periodontitis. Further study to evaluate the possible effects of these biological plaque control methods against periodontal disease is warranted.
More Related Videos
Related Concept Videos
Biological Methods for Microbial Control
Biofilms
Gene Regulation in Microbial Communities: Quorum Sensing
The Oral Microbiota
Microorganisms in Medicine and Therapeutics

