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Related Concept Videos

Randomized Experiments01:13

Randomized Experiments

The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
Blinding01:11

Blinding

Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and case-control studies.
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to subjects...
Crossover Experiments01:16

Crossover Experiments

Crossover experiments, also called the repeated-measurements design, is a study design in which all experimental units are exposed to all treatments in different periods. Crossover experiments are generally used in psychology, the pharmaceutical industry, agriculture, and medicine.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.

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Related Experiment Video

Updated: May 23, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

Partner randomized controlled trial: study protocol and coaching intervention.

Jane M Garbutt1, Gabrielle Highstein, Yan Yan

  • 1Department of Pediatrics, Division of Allergy and Pulmonary Medicine, Washington University, St Louis, MO 63110, USA. jgarbutt@dom.wustl.edu

BMC Pediatrics
|April 4, 2012
PubMed
Summary
This summary is machine-generated.

A telephone-coaching program improved asthma control in children by supporting parents in medication management and monitoring. This intervention reduced urgent care visits, enhancing quality of life for families managing persistent childhood asthma.

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E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

Area of Science:

  • Pediatric Pulmonology
  • Health Services Research
  • Behavioral Science

Background:

  • Childhood asthma frequently causes symptoms and activity limitations, leading to common urgent care visits.
  • Pediatricians often struggle to consistently monitor asthma control and educate families on self-management.
  • Disseminating effective asthma care interventions into routine practice remains a challenge.

Purpose of the Study:

  • To evaluate a 12-month telephone-coaching program for primary care management of children with persistent asthma.
  • To improve asthma control, enhance disease-related quality of life, and reduce urgent care events.
  • To assess the cost-effectiveness of the coaching intervention.

Main Methods:

  • A practice-level randomized controlled trial (RCT) involving 22 practices and 950 families with children aged 3-12 years with persistent asthma.
  • Intervention group received telephone coaching based on the transtheoretical model, targeting medication use and monitoring.
  • Control group received usual care; outcomes measured at 12 and 24 months via telephone interviews.

Main Results:

  • The study protocol describes a coaching intervention designed to support parents in managing their child's asthma.
  • Primary outcomes include changes in asthma control scores, parent quality of life, and urgent care events.
  • Secondary outcomes assess adherence to clinical guidelines, including medication prescriptions and regular care visits.

Conclusions:

  • The described intervention enrolled 950 families across 22 pediatric practices.
  • A detailed description of the telephone-coaching intervention is provided.
  • The study aims to demonstrate the feasibility and impact of a scalable asthma management program.