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Buclizine.

Gamal A E Mostafa, Abdullah A Al-Badr

    Profiles of Drug Substances, Excipients, and Related Methodology
    |April 4, 2012
    PubMed
    Summary
    This summary is machine-generated.

    This profile details buclizine hydrochloride, a sedating antihistamine effective for preventing motion sickness and migraine. It covers its preparation, physical traits, and analytical methods for comprehensive understanding.

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    Area of Science:

    • Pharmacology
    • Analytical Chemistry

    Background:

    • Buclizine hydrochloride is a piperazine derivative.
    • It functions as a sedating antihistamine with antimuscarinic properties.
    • Its primary application is in preventing motion sickness and migraine due to its antiemetic effects.

    Purpose of the Study:

    • To create a comprehensive profile of buclizine hydrochloride.
    • To detail its description, uses, preparation, physical characteristics, analysis, and stability.

    Main Methods:

    • Characterization involved solubility, melting range, X-ray powder diffraction, UV/Vis spectroscopy, IR spectroscopy, NMR (proton and carbon-13), and mass spectrometry.
    • Analytical methods included British Pharmacopoeia (BP) compendial methods, spectrophotometry, potentiometry, and various chromatography techniques (TLC, GC, HPLC).

    Main Results:

    • The profile systematically documents the physical and chemical properties of buclizine hydrochloride.
    • Established analytical methodologies for its quality control and identification.

    Conclusions:

    • Buclizine hydrochloride is a well-characterized compound with established analytical methods.
    • This profile serves as a valuable resource for researchers and pharmaceutical professionals.