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Related Concept Videos

Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
Cerebral Edema l: Introduction01:19

Cerebral Edema l: Introduction

Cerebral edema is a pathological increase in brain water content that disrupts intracranial pressure regulation and impairs neurological function. Because the cranial vault is rigid, even modest increases in tissue volume can compromise cerebral perfusion, distort neural structures, and initiate secondary injury. Cerebral edema develops through four principal mechanisms: vasogenic, cytotoxic, interstitial, and ionic.Vasogenic EdemaVasogenic edema arises from disruption of the blood–brain...
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...

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Updated: May 23, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
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Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Dural based mass: malignant or benign.

Kurt Scherer1, John Johnston, Mukta Panda

  • 1Department of Internal Medicine, University of Tennessee-Chattanooga, Chattanooga, TN, USA.

Journal of Radiology Case Reports
|April 4, 2012
PubMed
Summary
This summary is machine-generated.

A rare case of colonic adenocarcinoma mimicking a meningioma highlights the importance of diagnostic imaging and histopathology in differentiating dural lesions. Accurate diagnosis is crucial for effective treatment of brain metastases.

Keywords:
Dural based massmeningiomametastatic dural based lesions

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Area of Science:

  • Neurology
  • Oncology
  • Pathology

Background:

  • A 68-year-old female presented with colonic adenocarcinoma metastatic to the lungs and a parafalcine brain lesion initially suspected to be a meningioma.
  • Despite chemotherapy, the patient developed neurological deficits, and the brain lesion enlarged, suggesting a more aggressive pathology.

Purpose of the Study:

  • To report an uncommon case of metastatic colon cancer mimicking a meningioma.
  • To emphasize the diagnostic challenges and the importance of histopathology in differentiating dural lesions.

Main Methods:

  • Review of clinical presentation, imaging studies (CT, MRI, cerebral angiogram), and histopathological findings.
  • Surgical intervention involving embolization and excision of the suspected meningioma.

Main Results:

  • Pathology revealed metastatic adenocarcinoma from a colonic primary, not a meningioma.
  • The parafalcine lesion, initially presumed to be a meningioma based on imaging, was confirmed as metastatic cancer.

Conclusions:

  • Dural metastatic tumors can uncommonly mimic meningiomas, especially from a colonic primary.
  • Distinguishing benign dural tumors from malignant metastases requires comprehensive evaluation, including advanced imaging and definitive histopathological analysis.