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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Myasthenia Gravis ll: Pathophysiology01:22

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The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...

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Updated: May 23, 2026

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
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Published on: October 13, 2023

Multiple sclerosis in Oman.

John J Tharakan1, Ranganath P Chand, Poovathoor C Jacob

  • 1Department of Medicine, Sultan Qaboos University, Oman.

Neurosciences (Riyadh, Saudi Arabia)
|April 5, 2012
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis (MS) incidence is low in Oman, similar to the region. The clinical profile of MS in Oman, including the frequent optico-spinal form, aligns with Asian and Arabian Peninsula findings.

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Area of Science:

  • Neurology
  • Epidemiology

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease with varying clinical presentations globally.
  • Understanding regional variations in MS is crucial for diagnosis and management.

Purpose of the Study:

  • To characterize the clinical features of multiple sclerosis (MS) in Oman.
  • To compare Omani MS cases with those from the Arabian Peninsula, Asia, and Western countries.

Main Methods:

  • A descriptive, hospital-based study of 30 MS patients at Sultan Qaboos University Hospital (1990-2000).
  • Data collection included patient demographics, clinical symptoms, lesion distribution, disease course, and limited laboratory analyses (CSF oligoclonal bands, HLA).

Main Results:

  • Prevalence in Oman was 4/100,000, with a mean age at onset of 27 and a male-to-female ratio of 1.1:1.
  • Visual and motor symptoms were most common; optic nerve and spinal cord lesions were frequent.
  • The optico-spinal form occurred in 30% of patients, and the relapsing-remitting course was most prevalent (77%).

Conclusions:

  • MS incidence in Oman is low but comparable to regional data.
  • The clinical characteristics of MS in Oman, particularly the optico-spinal form, resemble those reported in Asia and the Arabian Peninsula.
  • The study highlights the similarity of MS clinical profiles across Oman and other Asian regions.