Related Experiment Video
Updated: May 23, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
C-reactive protein and the Framingham coronary risk score in patients newly diagnosed with intermittent claudication:
Yousef Shahin1, Josie Hatfield, Ian Chetter
1Academic Vascular Surgical Unit, Hull York Medical School & University of Hull, Hull, UK. yousef.shahin@yahoo.co.uk
Objective:
To investigate the relationship between serum C-reactive protein (CRP) levels and the calculated 10-year Framingham risk score (FRS) in patients newly diagnosed with intermittent claudication.
Methods:
Serum CRP levels were measured in 90 patients newly diagnosed with intermittent claudication over a 12-month period. In all, 76 patients (53 males [70%], mean age 63.3 ± 9.3) were included in the analysis.
Results:
Log-transformed CRP levels significantly correlated with total FRS (r = .34, P = .002). Participants were divided into 4 groups according to log-CRP levels. Analysis of variance showed a statistically significant difference between the 4 groups in terms of mean FRS, P = .003. Post hoc comparisons indicated that group 1 was significantly different from group 4, P = .002. Analysis of covariance showed a significant difference between the 4 groups of log-CRP levels in terms of mean FRS, P = .008.
Conclusion:
There is an increased 10-year risk of coronary heart disease associated with increased plasma concentration of CRP in patients newly diagnosed with intermittent claudication.
Related Concept Videos
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
Acute Coronary Syndrome III: Diagnostic Studies
Peripheral Artery Disease III: Interprofessional Care
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Coronary Artery Disease V: Interprofessional Care
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
