Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interleukin-6 in Natural and Pathophysiological Kidney Aging.

Cells·2026
Same author

Senotherapeutics for Brain Aging Management.

Neurology international·2025
Same author

Inflammation and vasopressin hypersecretion in aging.

Frontiers in endocrinology·2025
Same author

Correction: Inflammation and vasopressin hypersecretion in aging.

Frontiers in endocrinology·2025
Same author

DNA and Histone Modifications Identify a Putative Controlling Element (CE) on the X Chromosome of <i>Sciara coprophila</i>.

Cells·2025
Same author

A Biophysics of Epigenetic Rejuvenation.

Cells·2025
Same journal

The Nuclear Export Signal of IκBα Drives RelB Oscillations in the Noncanonical NF-κB Pathway.

Genes to cells : devoted to molecular & cellular mechanisms·2026
Same journal

The SQSTM1 L341V Variant Associated With Sporadic ALS Promotes the Accumulation of Enlarged Ubiquitin-Positive SQSTM1 Bodies.

Genes to cells : devoted to molecular & cellular mechanisms·2026
Same journal

Partial Depletion of SART1 Selectively Induces Mitotic Defects and Cell Death in Cancer Cells.

Genes to cells : devoted to molecular & cellular mechanisms·2026
Same journal

FOXO1 Is Required for Growth and Viability of Cancer-Associated Fibroblasts in Human Breast Carcinomas.

Genes to cells : devoted to molecular & cellular mechanisms·2026
Same journal

Strain-Dependent Functional Variation of a Sex Specific Sox9 Enhancer.

Genes to cells : devoted to molecular & cellular mechanisms·2026
Same journal

An Outflow Tract Myocardium-Specific Enhancer at the Sema3c Locus During Heart Development.

Genes to cells : devoted to molecular & cellular mechanisms·2026
See all related articles

Related Experiment Video

Updated: May 23, 2026

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
09:10

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Published on: January 30, 2026

Epigenetic rejuvenation.

Maria Manukyan1, Prim B Singh

  • 1Albert-Ludwigs-Universität Freiburg, BIOSS Centre for Biological Signalling Studies, Zentrum für Biosystemanalyse - ZBSA, Habsburgerstrasse 49, 79104 Freiburg, Germany.

Genes to Cells : Devoted to Molecular & Cellular Mechanisms
|April 11, 2012
PubMed
Summary
This summary is machine-generated.

Epigenetic rejuvenation offers a safer, faster, and cheaper alternative to induced pluripotent stem (iPS) cells for regenerative medicine. This method rejuvenates cells without altering their specialized functions, avoiding iPS cell-related risks.

More Related Videos

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells
08:01

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells

Published on: August 29, 2020

Related Experiment Videos

Last Updated: May 23, 2026

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
09:10

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Published on: January 30, 2026

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells
08:01

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells

Published on: August 29, 2020

Area of Science:

  • Regenerative Medicine
  • Epigenetics
  • Cell Biology

Background:

  • Induced pluripotent stem (iPS) cells offer potential for patient-specific regenerative therapies.
  • Current iPS cell therapies face challenges regarding safety, genetic abnormalities, and time efficiency.
  • Epigenetic rejuvenation is explored as an alternative approach to revitalize aged cells.

Purpose of the Study:

  • To investigate epigenetic rejuvenation as a novel strategy for regenerative medicine.
  • To compare the advantages of epigenetic rejuvenation over existing iPS cell technologies.
  • To discuss potential model systems for understanding epigenetic rejuvenation mechanisms.

Main Methods:

  • Exploration of epigenetic rejuvenation by modifying key epigenetic modifiers.
  • Discussion of model systems to elucidate the underlying mechanisms of epigenetic rejuvenation.
  • Comparative analysis of epigenetic rejuvenation with iPS cell-based therapies.

Main Results:

  • Epigenetic rejuvenation avoids the genetic and epigenetic abnormalities associated with the iPS cell de-/redifferentiation cycle.
  • This method retains the specialized functions of differentiated cells, bypassing transcriptional memory issues.
  • Epigenetic rejuvenation is significantly faster (days) compared to iPS cell production (weeks).

Conclusions:

  • Epigenetic rejuvenation presents a safer, more rapid, and cost-effective pathway for regenerative medicine.
  • It overcomes key limitations of current iPS cell technologies, offering a promising alternative.
  • Further research into model systems is needed to fully understand and harness epigenetic rejuvenation.