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Updated: May 23, 2026

Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Isoleucine-catalyzed direct asymmetric aldol addition of enolizable aldehydes
Kerstin Rohr1, Rainer Mahrwald
1Institute of Chemistry, Humboldt-University, Brook-Taylor Sr. 2, 12489 Berlin, Germany.
Abstract:
Isoleucine-catalyzed direct enantioselective aldol additions between enolizable aldehydes are reported. Intermediate acetal structures dictate the configurative outcome and were supported by a hydrogen bond. This direct isoleucine-catalyzed aldol addition represents a welcome complement to both proline- and histidine-catalyzed aldol additions of enolizable aldehydes.
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