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Updated: May 23, 2026

Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography
Published on: February 9, 2019
[Focus on clinical application of optical coherence tomography and image analysis]
Abstract:
Optical coherence tomography (OCT) is a non-invasive, high-resolution imaging modality to acquire cross-sections and three-dimensional images of the microstructure in biological specimens. Because of rapid improvement of acquisition speed and axial resolution of OCT over recent years, OCT is becoming increasingly used in clinic for diagnosing or analyzing diseases of the eye, especially in the fundus. However, OCT has been used regardless of the location of lesions and the clarity of optical media. This misuse wastes resources and delays diagnosis and treatment of certain ocular diseases. Furthermore, the image of SD-OCT cannot be analyzed completely at present. Therefore, how to apply OCT in clinic appropriately and to analyze its image professionally is crucial, which should attract the attention of ophthalmologists. In addition, comprehensively analyzing ocular diseases combined with other examinations is extremely important to improve the level of diagnosis.
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