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Related Concept Videos

Enzyme-Linked Immunosorbent Assay01:33

Enzyme-Linked Immunosorbent Assay

In 1971, Peter Perlman and Eva Engvall developed an Enzyme-linked immunosorbent assay (ELISA or EIA). ELISA differs from western blot in that the assays are conducted in microtiter plates or in vivo rather than on an absorbent membrane.
There are many different types of ELISAs, but they all involve an antibody molecule whose constant region binds an enzyme, leaving the variable region free to bind its specific antigen.  Enzyme-substrate reaction allows the antigen to be visualized or quantified.
Bacterial Toxins01:12

Bacterial Toxins

Bacterial toxins are sophisticated virulence factors that enable pathogenic bacteria to interact with, invade, and damage host tissues. These toxins fall broadly into two types: protein exotoxins, which are secreted into the environment and target specific host receptors, and lipopolysaccharide endotoxins, which are structural components of the bacterial outer membrane released primarily during bacterial lysis or membrane shedding. Exotoxins generally act more selectively, binding to cell...

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BacterialLectinDb: An integrated bacterial lectin database.

Dharmendra Kumar, Yashoda Mittal

    Bioinformation
    |April 12, 2012
    PubMed
    Summary
    This summary is machine-generated.

    A new bacterial lectin database, BacterialLectinDb, aids research into infectious diseases and vaccine development. This resource centralizes bacterial lectin data for enhanced proteomics and genomics exploration.

    Keywords:
    Bacterial LectinsBacterial VaccinesData CurationGlycan Specificity and Structure AnnotationLectin- Genome/Proteome

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    Area of Science:

    • Microbiology
    • Bioinformatics
    • Immunology

    Background:

    • Bacterial lectins are crucial for understanding infectious diseases and developing vaccines.
    • Existing data on bacterial lectins is fragmented, hindering comprehensive research.
    • Proteomics and genomics research can benefit from centralized lectin information.

    Purpose of the Study:

    • To create a centralized repository for bacterial lectin data.
    • To facilitate research in proteomics and genomics related to infectious diseases.
    • To support the development of novel bacterial vaccines and prevention strategies.

    Main Methods:

    • Designed and developed a comprehensive bacterial lectin database named BacterialLectinDb.
    • Utilized HTML and XML for database schema design and implementation.
    • Organized diverse information on bacterial lectins into a central repository.

    Main Results:

    • BacterialLectinDb provides an organized schema for collating bacterial lectin information.
    • The database serves as a valuable tool for biotechnologists and geneticists.
    • Facilitates deeper understanding in proteomics and genomics research.

    Conclusions:

    • BacterialLectinDb is a promising tool for advancing infectious disease research.
    • The database supports the exploration of molecular mechanisms of diseases.
    • Aids in developing new approaches for disease prevention and bacterial vaccine creation.