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Updated: May 23, 2026

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyl(tropone)iron
Published on: August 12, 2019
Iron-catalyzed cyclopropanation with glycine ethyl ester hydrochloride in water
Bill Morandi1, Amund Dolva, E M Carreira
1Laboratory of Organic Chemistry, ETH-Zürich , HCI H335, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland.
Abstract:
An iron-catalyzed cyclopropanation reaction of styrenes in aqueous media is disclosed that employs glycine ethyl ester hydrochloride in a tandem diazotization/cyclopropanation reaction. The products are accessed in good yields and good diastereoselectivity using readily available and inexpensive starting materials. Moreover, a wide range of transition metals may be used under these conditions, thus opening new opportunities for efficient carbene-transfer reactions under user-friendly conditions.
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