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[Observations on the corneal endothelium in glaucoma]
1Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangdong Province.
Summary
Glaucoma and its treatments can decrease corneal endothelial cell density. Pre-operative assessment and intraocular surgical precautions are vital to protect these essential cells.
Area of Science:
- Ophthalmology
- Cell Biology
Context:
- Unilateral glaucoma affects corneal endothelial cells.
- Specular microscopy is used for endothelial cell assessment.
Purpose:
- To evaluate corneal endothelial cell density in unilateral glaucoma patients.
- To compare cell density between different glaucoma types and post-surgical eyes.
Summary:
- Corneal endothelial cell density was reduced in eyes with acute angle-closure glaucoma (12.7%), chronic angle-closure glaucoma (5.34%), and glaucoma cyclitis syndrome (12.4%).
- Filtering operations led to a 10.2% decrease, while Nd:YAG laser iridotomy resulted in a 5.11% decrease in endothelial cell density.
- Risk factors like trauma, uveitis, high IOP, age, and prior surgery increase the risk of endothelial damage.
Impact:
- Highlights the need for pre-operative endothelial cell evaluation.
- Emphasizes the importance of protecting the corneal endothelium during intraocular surgeries.
- Informs surgical planning and patient management in glaucoma care.