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Updated: May 23, 2026

Protocol for Dengue Infections in Mosquitoes (A. aegypti) and Infection Phenotype Determination
Published on: July 4, 2007
Host genetic susceptibility to severe dengue infection
Nguyen Thi Phuong Lan1, Kenji Hirayama
1Department of Microbiology and Immunology, Pasteur Institute Ho Chi Minh City, Vietnam.
Abstract:
Epidemiological evidence indicates that host genetic factors are relevant and predispose DHF/DSS development. Here, we review the host genetic studies concerning human leucocyte antigens, antibody receptors, immune/inflammatory mediators, attachment molecules, cytokines and other factors exerting an immunoregulatory effect as well as the current genome-wide association studies. We also discuss some viewpoints on future challenges related to the design of safe and effective prevention and treatment options.
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