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Updated: May 23, 2026
10:33
Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis
Published on: December 17, 2021
Uveitis and common variable immunodeficiency: data from the DEF-I study and literature review
Florian Pasquet1, Laurent Kodjikian, Frédéric Mura
1Department of Internal Medicine, Hôpital Croix-Rousse, Lyon, France.
Ocular Immunology and Inflammation
|April 18, 2012
Summary
Common variable immunodeficiency (CVID) can manifest with chronic uveitis, often bilateral and granulomatous. Uveitis may be an early sign, prompting consideration of CVID diagnosis.
Area of Science:
- Ophthalmology
- Immunology
- Rheumatology
Background:
- Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by impaired antibody production.
- Ocular manifestations in CVID are not well-defined, but inflammatory conditions can occur.
Purpose of the Study:
- To investigate the association between uveitis and common variable immunodeficiency (CVID).
- To determine the clinical characteristics and management of uveitis in CVID patients.
Main Methods:
- Retrospective analysis of patients within the French DEFI cohort of adults with CVID.
- Literature review to identify additional cases of CVID-associated uveitis.
Main Results:
- Four CVID patients with uveitis were identified in the DEFI cohort (1.6% frequency).
- Literature search yielded ten additional cases, totaling 14 patients.
- Uveitis was consistently chronic, typically bilateral (11/14) and granulomatous (9/14).
- Seven patients exhibited a 'sarcoid-like' syndrome; nine had granulomatous uveitis suggestive of ocular sarcoidosis.
- Treatment involved local corticosteroids (5/14) and systemic therapy (9/14), including corticosteroids and/or immunosuppressive agents.
Conclusions:
- Uveitis can be a presenting manifestation of CVID.
- Consideration of CVID is crucial in patients diagnosed with uveitis, especially those with chronic or granulomatous forms.
- Early diagnosis of CVID may facilitate timely management of associated ocular inflammation.
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