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Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

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Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

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Updated: May 23, 2026

Electrophysiological Measurements and Analysis of Nociception in Human Infants
09:18

Electrophysiological Measurements and Analysis of Nociception in Human Infants

Published on: December 20, 2011

Effective analgesia using physical interventions for infant immunizations.

John W Harrington1, Stacey Logan, Courtney Harwell

  • 1Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia , USA. John.Harrington@chkd.org

Pediatrics
|April 18, 2012
PubMed
Summary
This summary is machine-generated.

The 5 S's (swaddling, side/stomach position, shushing, swinging, and sucking) significantly reduced infant pain and crying during vaccinations. Combining the 5 S's with sucrose did not offer additional pain relief compared to the 5 S's alone.

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06:29

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Published on: November 29, 2017

Area of Science:

  • Pediatrics
  • Pain Management
  • Neonatal Care

Background:

  • Routine immunizations are a common source of acute pain for infants.
  • Non-pharmacological interventions are sought to manage vaccination-associated pain.
  • The 5 S's (swaddling, side/stomach position, shushing, swinging, and sucking) are a set of comfort measures.

Purpose of the Study:

  • To evaluate the analgesic effectiveness of the 5 S's alone and combined with sucrose.
  • To assess the impact of these interventions on infant pain and crying during immunizations.

Main Methods:

  • Prospective, randomized, placebo-controlled trial involving 2- and 4-month-old infants.
  • Four groups: water/control, sucrose alone, 5 S's alone, and 5 S's with sucrose.
  • Pain assessed using the Modified Riley Pain Score; crying duration also measured.

Main Results:

  • The 5 S's intervention, alone or with sucrose, resulted in significantly lower mean pain scores and crying duration compared to control and sucrose alone.
  • No significant difference in pain scores or crying was observed between the 5 S's group and the 5 S's with sucrose group.
  • A clear trend showed 5 S's and sucrose groups had the lowest pain, followed by sucrose alone, then the control group.

Conclusions:

  • The 5 S's intervention effectively reduces pain and crying in infants during routine vaccinations.
  • Adding sucrose to the 5 S's does not provide additional analgesic benefits.
  • The 5 S's represent a valuable non-pharmacological approach for managing infant vaccination pain.