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Updated: May 23, 2026

Electrophysiological Measurements and Analysis of Nociception in Human Infants
Published on: December 20, 2011
John W Harrington1, Stacey Logan, Courtney Harwell
1Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia , USA. John.Harrington@chkd.org
The 5 S's (swaddling, side/stomach position, shushing, swinging, and sucking) significantly reduced infant pain and crying during vaccinations. Combining the 5 S's with sucrose did not offer additional pain relief compared to the 5 S's alone.
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