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Updated: May 23, 2026

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions
Published on: March 8, 2019
[Morphology and etiopathogenesis of the abdominal aortic aneurysm]
Lada Eberlová1, Zbynek Tonar, Vera Krízková
1Ustav histologie a embryologie Lékarské fakulty UK, Plzen. lada.eberlova@lfp.cuni.cz
Abstract:
The paper summarizes the latest research on the abdominal aorta aneurysm etiopathogenesis and compares normal aorta morphology with changes in the aortic aneurysm wall. The role of risk factors, especially hemodynamic and genetic, is discussed in detail. Special attention is paid to inflammatory processes including cytokines and matrix degrading proteases that contribute to the development of aneurysm. The role of thrombus and the current results of research into biomarkers indicating the risks and progression of the disease are analysed. Finally, a review of pharmacomodulation of the aortic aneurysm using statins, antibiotics, antihypertensive and nonsteroidal antiinflammatory drugs is presented.
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