Related Experiment Video
Updated: May 23, 2026

Animal Model of Implant-Associated Infections in Mice
Published on: June 27, 2025
Nanomaterial-based treatments for medical device-associated infections
1Department of Orthopaedics, Rhode Island Hospital and Alpert Medical School, Brown University, Providence, RI 02903, USA. nhiem_tran@brown.edu
Abstract:
Bacterial infections remain one of the biggest concerns to our society. Conventional antibiotic treatments showed little effect on the increasing number of antibiotic-resistant bacteria. Advances in synthetic chemistry and nanotechnology have resulted in a new class of nanometer-scale materials with distinguished properties and great potential to be an alternative for antibiotics. In this Minireview, we address the current situation of medical-device-associated infections and the emerging opportunities for antibacterial nanomaterials in preventing these complications. Several important antimicrobial nanomaterials emergent from advances in synthesis chemistry are introduced and their bactericidal mechanisms are analyzed. In addition, concerns regarding the biocompatibility of such materials are also addressed.
Related Concept Videos
Microbial Corrosion
Bacterial Signaling
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Clinical Significance of Antibiotic Resistance
Physical Methods for Controlling Microbial Growth: Radiation and Filtration

