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6-Deoxyerythronolide B synthase thioesterase-catalyzed macrocyclization is highly stereoselective

Atahualpa Pinto1, Meng Wang, Mark Horsman

  • 1Department of Chemistry, Centre for Catalysis Research and Innovation, University of Ottawa, Ottawa, ON, Canada T1N 6N5.

Organic Letters
|April 24, 2012
PubMed
Summary

The study demonstrates that the erythromycin polyketide synthase thioesterase (DEBS TE) precisely controls macrocyclization. This enzyme exhibits high stereospecificity and regioselectivity, crucial for synthesizing therapeutic polyketide natural products.

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