Related Experiment Video
Updated: May 23, 2026

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
Published on: January 31, 2025
Targeting the hedgehog pathway: role in cancer and clinical implications of its inhibition
1Division of GI Oncology, NYU Cancer Institute, 160 East 34th Street, New York, NY 10016, USA. Deirdre.Cohen@nyumc.org
Abstract:
The Hedgehog (Hh) pathway is a signaling cascade that is evolutionally highly conserved and plays an important role in embryonic pattern formation and stem cell response to tissue damage. Given the pivotal role the Hh pathway plays in embryonic development in terms of proliferation and differentiation, it is not surprising that it has also been implicated in tumorigenesis and tumor growth acceleration in a vast variety of malignancies. This article summarizes the mechanism of Hh pathway signal transduction, discusses the models of pathway activation, reviews the clinical data using Hh inhibitors, and discusses challenges to the development of pathway inhibitors.
Related Concept Videos
Hedgehog Signaling Pathway
Hedgehog Signaling Pathway
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Inhibition of Cdk Activity
Inhibition of CDK Activity
Mitogens and the Cell Cycle

