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Neurologic indications for therapeutic plasma exchange: 2011 update
Kelly Gwathmey1, Rasheed A Balogun, Ted Burns
1Department of Neurology, The University of Virginia, Charlottesville, Virginia, USA.
Journal of Clinical Apheresis
|April 24, 2012
Summary
Therapeutic plasma exchange (TPE) is a common treatment for neurological disorders. This review details TPE
Area of Science:
- Neurology
- Immunology
- Nephrology
Background:
- Therapeutic plasma exchange (TPE) is a widely utilized treatment modality in neurology.
- Several neurological conditions have demonstrated responsiveness to TPE.
Purpose of the Study:
- To review the primary neurological indications for therapeutic plasma exchange (TPE).
- To discuss the efficacy and considerations for TPE in specific neurological diseases.
Main Methods:
- Literature review of common neurologic indications for TPE.
- Focus on Guillain-Barre' syndrome and myasthenia gravis.
- Inclusion of other conditions such as CIDP, LEMS, MS, NMO, and PML.
Main Results:
- TPE is a recognized treatment for Guillain-Barre' syndrome and myasthenia gravis.
- Evidence supports TPE use in chronic inflammatory demyelinating polyneuropathy, Lambert-Eaton syndrome, and certain autoimmune conditions.
- Considerations for TPE include efficacy, cost, side effects, and availability.
Conclusions:
- Therapeutic plasma exchange is a critical treatment option for various neurological disorders.
- Neurologists must weigh the benefits against risks and practicalities before initiating TPE.
- Further research may refine TPE protocols for optimal patient outcomes.
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