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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Microenvironments01:22

Microenvironments

Microorganisms inhabit highly localized spaces known as microenvironments, which are defined by distinct physical and chemical characteristics. These include oxygen concentration, pH, temperature, light availability, and nutrient levels. The conditions within a microenvironment can differ markedly from those in the surrounding area and significantly influence microbial growth, metabolism, and community structure.Microenvironments often display sharp physicochemical gradients over small spatial...

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An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth
09:14

An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth

Published on: August 11, 2011

Microenvironments dictating tumor cell dormancy.

Paloma Bragado1, Maria Soledad Sosa, Patricia Keely

  • 1Division of Hematology and Oncology, Department of Medicine, Department of Otolaryngology, Mount Sinai School of Medicine, Tisch Cancer Institute, Black Family Stem Cell Institute, New York, NY, USA.

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer
|April 25, 2012
PubMed
Summary
This summary is machine-generated.

Tumor cell dormancy is a survival strategy. We explore three scenarios: stress signals, therapy priming, and early dissemination, to understand and target dormant tumor cells, preventing metastasis.

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Area of Science:

  • Oncology
  • Cancer Biology
  • Metastasis Research

Background:

  • Mechanisms of disseminated tumor cell (DTC) dormancy are poorly understood.
  • Dormancy is a critical factor in cancer recurrence and metastasis.
  • Targeting dormant DTCs is essential for eradicating residual disease.

Purpose of the Study:

  • To review experimental and theoretical frameworks for DTC dormancy.
  • To elucidate potential scenarios driving tumor cell dormancy.
  • To provide a basis for targeting dormant DTCs to prevent metastasis.

Main Methods:

  • Discussion of experimental evidence.
  • Review of theoretical frameworks.
  • Analysis of clinical evidence supporting proposed scenarios.

Main Results:

  • Three potential scenarios for DTC dormancy are proposed: stress-induced dormancy, therapy/micro-environment-primed dormancy, and early dissemination dormancy.
  • DTC dormancy is presented as a survival strategy.
  • Evidence supporting these non-mutually exclusive scenarios is reviewed.

Conclusions:

  • Understanding DTC dormancy mechanisms is key to developing effective cancer therapies.
  • Targeting dormant DTCs represents a promising strategy to prevent metastasis.
  • Further research into these scenarios can guide clinical interventions against residual cancer cells.