Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regulatory T cell attracting therapy accelerates skeletal muscle functional recovery following injury.

Scientific reports·2026
Same author

Lipid stress evolved, microbiome-based probiotics reduce lipid uptake in mice.

Bioengineering & translational medicine·2026
Same author

A Lecithin Liposome Stimulates Soil Microbial Respiration and Nitrate Immobilization.

ACS agricultural science & technology·2025
Same author

Treating periodontal disease: from antimicrobials to immunomodulation.

Trends in pharmacological sciences·2025
Same author

Monitoring Vaccine-Induced Antibody Levels Using Carbon Nanotube-Based Field-Effect Transistors.

Analytical chemistry·2025
Same author

Expression and characterization of SARS-CoV-2 spike protein in Thermothelomyces heterothallica C1.

Vaccine·2025

Related Experiment Video

Updated: May 22, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Biomimetic delivery with micro- and nanoparticles.

Stephen C Balmert1, Steven R Little

  • 1Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA 15261 USA.

Advanced Materials (Deerfield Beach, Fla.)
|April 25, 2012
PubMed
Summary
This summary is machine-generated.

Biomimetic delivery uses micro- and nanoparticles (MNP) inspired by cell communication for therapies. These systems focus on controlled release, surface ligand presentation, and particle physical properties, mimicking natural cells for advanced treatments.

More Related Videos

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
09:41

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
08:02

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Published on: November 7, 2013

Related Experiment Videos

Last Updated: May 22, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
09:41

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
08:02

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Published on: November 7, 2013

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Biomimetic delivery systems leverage principles of cellular communication to design advanced therapeutic agents.
  • Micro- and nanoparticles (MNP) are increasingly investigated for their potential to mimic biological systems.
  • Current research explores various strategies for temporospatial presentation of biological signals.

Purpose of the Study:

  • To review the advancements in biomimetic delivery using micro- and nanoparticles (MNP).
  • To focus on key aspects of biomimetic MNP systems including controlled release, ligand presentation, and physical properties.
  • To discuss the implications of sophisticated biomimetic MNP systems, including regulatory considerations.

Main Methods:

  • Review of literature on biomimetic delivery systems.
  • Analysis of MNP formulations for controlled release of soluble factors.
  • Investigation of surface-bound ligand presentation strategies (isotropic to anisotropic).
  • Examination of particle physical properties (size, shape, stiffness) mimicking cells.

Main Results:

  • Biomimetic MNP systems effectively utilize controlled release, surface ligand presentation, and physical property mimicry.
  • Multimodal or multifactor delivery, analogous to human communication, is crucial for most biomimetic MNP systems.
  • The sophistication of these "cell-like" MNP systems presents unique regulatory challenges.

Conclusions:

  • Biomimetic delivery with MNP is a rapidly advancing field with significant therapeutic potential.
  • The integration of temporal and spatial signaling, along with physical mimicry, defines effective biomimetic MNP strategies.
  • Future development requires careful consideration of regulatory frameworks for these advanced nanomedicines.