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Updated: May 22, 2026
Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
Published on: March 25, 2019
Nano cancer therapy strategies
1Department of Oral Pathology and Microbiology, School of Dental Sciences, Sharda University, Delhi, India. manjultiw@gmail.com
Abstract:
Cancer is a leading cause of deaths. Millions of people are diagnosed with cancer every year. Many cancer cells have a protein all over their surface, while healthy cells typically do not express the protein as strongly. By conjugating, or binding, the gold nanoparticles to an antibody the researchers were able to get the nanoparticles to attach themselves to the cancer cells which may help us unravel the inner workings of a cancer cell and produce better treatments. In terms of drug delivery systems, nano particles enable unique approaches for cancer treatment. A large number of nanoparticle delivery systems have been developed for cancer therapy and currently they are in the preclinical stages of development. More recently developed nanoparticles are demonstrating the potential sophistication of these delivery systems by incorporating multifunctional capabilities and targeting strategies in an effort to increase the efficacy of these systems against the most difficult cancer challenges. This article reviews the available preclinical and clinical nanoparticle technology platforms and their impact on cancer therapy.
Insights
Researchers are developing gold nanoparticles conjugated to antibodies to target cancer cells, potentially improving cancer treatments and drug delivery systems. This review covers nanoparticle platforms impacting cancer therapy.
Area of Science:
- Oncology
- Nanotechnology
- Biomedical Engineering
Background:
- Cancer remains a leading cause of death globally, with millions diagnosed annually.
- Cancer cells often overexpress specific surface proteins compared to healthy cells.
- Current cancer treatments face challenges, necessitating novel therapeutic strategies.
Purpose of the Study:
- To review nanoparticle technology platforms for cancer therapy.
- To explore the impact of these platforms on preclinical and clinical cancer treatment.
- To highlight advancements in multifunctional nanoparticles for enhanced efficacy.
Main Methods:
- Conjugating gold nanoparticles to antibodies for targeted cancer cell binding.
- Developing nanoparticle delivery systems for cancer treatment.
- Reviewing existing preclinical and clinical nanoparticle technologies.
Main Results:
- Nanoparticle-antibody conjugates demonstrate potential for specific cancer cell targeting.
- Nanoparticle drug delivery systems offer unique approaches to cancer therapy.
- Advanced nanoparticles incorporate multifunctionality and targeting for improved outcomes.
Conclusions:
- Nanoparticle technology platforms show significant promise in advancing cancer therapy.
- Targeted nanoparticle delivery can enhance treatment efficacy against challenging cancers.
- Further development of preclinical and clinical nanoparticle applications is crucial for future cancer treatment strategies.
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