Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Severe Hypertension: Evaluation and Treatment.

American family physician·2026
Same author

Heat-Related Illnesses.

American family physician·2026
Same author

Heart Failure With Reduced Ejection Fraction: Medical Management.

American family physician·2025
Same author

Palpitations: Evaluation, Management, and Wearable Smart Devices.

American family physician·2024
Same author

Managing Selected Chronic Conditions in Hospitalized Patients.

American family physician·2024
Same author

Cardiovascular Disease: Inflammatory and Infectious Heart Conditions.

FP essentials·2024
Same journal

Nausea and Vomiting During Pregnancy.

American family physician·2026
Same journal

Metabolic Dysfunction-Associated Steatotic Liver Disease: Diagnosis and Management.

American family physician·2026
Same journal

Type 2 Diabetes: Outpatient Insulin Management.

American family physician·2026
Same journal

Recurrent UTI in Women: Diagnosis and Management.

American family physician·2026
Same journal

Gambling Disorder: Diagnosis and Treatment.

American family physician·2026
Same journal

Pacemaker Therapy: Indications and Recommendations.

American family physician·2026
See all related articles

Related Experiment Video

Updated: May 22, 2026

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
09:46

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells

Published on: December 27, 2017

Thrombocytopenia.

Robert L Gauer1, Michael M Braun

  • 1Family Medicine Residency, Womack Army Medical Center, Fort Bragg, NC 28310, USA. Robert.gauer@us.army.mil

American Family Physician
|April 27, 2012
PubMed
Summary
This summary is machine-generated.

Thrombocytopenia, a low platelet count, requires investigation to determine its cause. Severity ranges from asymptomatic to life-threatening bleeding, necessitating tailored treatment based on etiology.

More Related Videos

Ferric Chloride-induced Murine Thrombosis Models
10:37

Ferric Chloride-induced Murine Thrombosis Models

Published on: September 5, 2016

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Related Experiment Videos

Last Updated: May 22, 2026

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
09:46

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells

Published on: December 27, 2017

Ferric Chloride-induced Murine Thrombosis Models
10:37

Ferric Chloride-induced Murine Thrombosis Models

Published on: September 5, 2016

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Area of Science:

  • Hematology
  • Internal Medicine

Background:

  • Thrombocytopenia, defined as a platelet count < 150 × 10(3)/µL, is often an incidental finding.
  • Platelet count correlates with bleeding risk, from asymptomatic to spontaneous hemorrhage.

Purpose of the Study:

  • To outline the diagnostic approach and management of thrombocytopenia.
  • To differentiate causes and severity of thrombocytopenia.

Main Methods:

  • Review of clinical presentation, history, physical examination, and laboratory findings.
  • Differential diagnosis based on patient presentation and platelet count.

Main Results:

  • Patients with platelet counts > 50 × 10(3)/µL are rarely symptomatic.
  • Severe thrombocytopenia (< 5 × 10(3)/µL) is a hematologic emergency.
  • Common causes include infections, drug reactions, immune disorders, pregnancy-related conditions, and hematologic disorders.

Conclusions:

  • Diagnosis relies on clinical evaluation and laboratory studies.
  • Treatment is etiology-specific, with some cases resolving upon treating the underlying cause.
  • Hematology consultation is advised for severe or worsening cases.