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Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
Published on: May 25, 2017
Modest alcohol consumption has an inverse association with liver fat content
Toshiaki Gunji1, Hajime Sato, Kimiko Iijima
1Center for Preventive Medicine, NTT Medical Center Tokyo, Tokyo, Japan.
Background/Aims:
Modest alcohol consumption has been suggested to be protective against alanine amino-transferase activities and ultrasonography-defined fat-ty liver. We aimed to explore the association between alcohol consumption and liver fat content as quantitative-ly determined by computed tomography (CT).
Methodology:
One-thousand two-hundred thirty-one Japanese males, aged over 40 years, voluntarily participated ina health check-up program including CT screening in 2009-2010. Exclusion criteria included positivity for the hepatitis B or C virus, abstinent alcoholics and potential hepatotoxic drug intake. Liver fat content, visceral adipose tissue (VAT) and subcutaneous adipose tis-sue were determined by CT. The association between alcohol consumption (g/week) and liver attenuation values (HU) was investigated by multivariate analysis with metabolic syndrome factors, liver enzyme activities and physical activities as covariates.
Results:
One-thousand one-hundred thirty-eight subjects were eligible for this cross-sectional survey. VAT, triglyceride, glycated hemoglobin and alanine aminotransferase were significant and independent predictors for a decrease of liver attenuation. Alcohol consumption had a significant and independent association with an increase in liver attenuation (correlation coefficient=0.007, 95%CI=0.004-0.011, p<0.001) after adjusting for potential confounding variables.
Conclusions:
Alcohol consumption has an inverse association with CT-determined liv-er fat content independent of metabolic syndrome factors, liver enzyme activities and physical activities.
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