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Published on: January 28, 2020
Association between resistin level and renal function in patients undergoing coronary artery bypass graft surgery
Hasan Gungor1, Bahadir Kirilmaz, Ali Zorlu
1Department of Cardiology, Odemis State Hospital, Izmir, Turkey. drgungorhasan@yahoo.com
Insights
Lower glomerular filtration rate is linked to higher resistin levels in patients undergoing coronary artery bypass graft surgery. This finding is independent of common heart disease risk factors.
Area of Science:
- Cardiology
- Nephrology
- Endocrinology
Background:
- Resistin is an adipokine implicated in metabolic and cardiovascular diseases.
- Renal function is a critical determinant of cardiovascular health.
- The relationship between resistin and renal function in patients undergoing coronary artery bypass graft (CABG) surgery requires further investigation.
Purpose of the Study:
- To investigate the association between serum resistin levels and renal function in patients scheduled for CABG surgery.
- To determine if resistin levels correlate with markers of renal function such as glomerular filtration rate (GFR), urea, and creatinine.
Main Methods:
- A cohort of 37 patients undergoing CABG surgery was studied.
- Blood samples were collected preoperatively to measure resistin, urea, creatinine, and GFR.
- Patients were stratified into lower and higher resistin level groups based on the median value.
Main Results:
- Resistin levels showed a significant positive correlation with urea and creatinine, and an inverse correlation with GFR.
- Resistin levels were also inversely correlated with the usage of statins and beta-blockers.
- Multivariate analysis revealed that only GFR remained independently associated with higher resistin levels (OR, 0.960; P=0.018).
Conclusions:
- Lower GFR is independently associated with higher circulating resistin levels in patients undergoing CABG surgery.
- These findings suggest a potential role for resistin in the pathophysiology of renal dysfunction in cardiac patients.
- An optimal GFR cutoff of 91 mL/min/1.73 m² was identified for predicting higher resistin levels.
Aim:
The purpose of this study was to evaluate the association between resistin levels and renal function in patients undergoing coronary artery bypass graft (CABG) surgery.
Methods:
Thirty-seven consecutive patients (mean ± SD, age 60 ± 10 years, 29 (78%) male) undergoing CABG surgery at our department were enrolled into our study. Blood samples were taken to examine quantities of resistin level and other blood parameters the day before surgery. The patients were categorized into 2 groups: lower resistin level (group 1) or higher resistin level (group 2) according to the median value of 9 ng/mL.
Results:
Mean ± SD resistin level, glomerular filtration rate (GFR), and urea and creatinine levels were 9.5 ± 4.2 ng/mL, 78 ± 25 mL/min per 1.73 m(2), 42 ± 14 mg/dL, and 1.08 ± 0.2 mg/dL, respectively. Resistin showed significant correlation with serum levels of urea (r = 0.448l P = 0.005), creatinine (r = 0.367; P = 0.026), inverse correlation with GFR (r = -0.398; P = 0.015), statin usage (r = -0.393; P = 0.016), and β-blocker usage (r = -0.365; P = 0.026). In the multivariate logistic regression model, only GFR (odds ratio, 0.960; 95 confidence interval, 0.928-0.993; P = 0.018) remained independently associated with higher resistin levels after adjustment of other potential confounders in patients undergoing CABG surgery. According to the receiver operating characteristics curve analysis, the optimal cutoff value of GFR to predict higher resistin levels was found as 91 mL/min or less per 1.73 m(2), with 100% sensitivity and 61.1% specificity.
Conclusion:
The present study demonstrated that a lower glomerular filtration rate was associated with higher circulating resistin levels, independent of coronary heart disease risk factors in patients undergoing CABG surgery.
