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Gastrointestinal tumours after stapler vs vicryl anastomoses in carcinogen-treated rats
Abstract:
Since nickel is a potent carcinogen the influence of nickel-containing staples on the frequency of gastrointestinal tumour formation was tested in caecum-resected and carcinogen-treated rats. Tumour formation was elevated after stapling compared with simple laparotomy or vicryl sutures. This demonstrates a potential hazard of stapling techniques. In the vicryl group there was only one suture line carcinoma.