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The influence of bone substitute materials on the bone volume after maxillary sinus augmentation: a microcomputerized
Sebastian Kühl1, Christoph Brochhausen, Hermann Götz
1School of Dental Medicine, Department of Oral Surgery, Oral Radiology and Oral Medicine, University of Basel, Hebelstrasse 3, 4056 Basel, Switzerland. sebastian.kuehl@unibas.ch
Clinical Oral Investigations
|April 28, 2012
Summary
Adding bone substitute materials (BSM) to particulated autogenous bone (PAB) for maxillary sinus augmentation does not change new bone formation. This approach may reduce the required amount of PAB and donor site morbidity.
Area of Science:
- Oral and Maxillofacial Surgery
- Regenerative Medicine
- Biomaterials Science
Background:
- Maxillary sinus augmentation is a common procedure to enhance bone volume for dental implant placement.
- Particulated autogenous bone (PAB) is frequently used, but its harvest can lead to donor site morbidity.
- Bone substitute materials (BSM) are explored to augment PAB and potentially reduce autograft volume.
Purpose of the Study:
- To evaluate the effect of adding BSM (beta-tricalciumphosphate [β-TCP] and hydroxyapatite [HA]) to PAB on the volume fraction of newly formed bone after maxillary sinus augmentation.
- To compare bone regeneration in groups using PAB alone versus PAB combined with different BSM ratios.
Main Methods:
- Thirty patients undergoing maxillary sinus augmentation were randomized into three groups: PAB alone, PAB/β-TCP, and PAB/HA/β-TCP.
- Graft material samples were analyzed using microcomputerized tomography (μ-CT) at the time of augmentation.
- Grafted bone samples were harvested after 5 months and analyzed again with μ-CT to determine the volume fraction of newly formed bone.
Main Results:
- A statistically significant increase in bone volume fraction was observed in all groups after 5 months of healing (p < 0.05).
- There were no statistically significant differences in the increase of bone volume fraction between the groups.
- The addition of BSM to PAB did not significantly alter the new bone formation compared to PAB alone.
Conclusions:
- The addition of β-TCP or HA/β-TCP to PAB does not influence the increase in bone volume fraction after maxillary sinus augmentation.
- Incorporating BSM with PAB may allow for a reduction in the quantity of PAB needed, potentially minimizing donor site morbidity.