[Cardiac resynchronization therapy: mortality, rehospitalization, and procedure-related complications. A three-year

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Updated: May 22, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Vittorio Palmieri1, Salvatore Pezzullo, Fernando Coltorti

  • 1U.O.C di Cardiologia, Ospedaliero dei Pellegrini, ASL, Napoli. vpalmieri68@gmail.com

Giornale Italiano Di Cardiologia (2006)
|April 28, 2012
PubMed

Insights

Cardiac resynchronization therapy with an implantable defibrillator (CRT-D) showed comparable benefits across different patient indication classes. This real-world study found similar outcomes in mortality, heart failure hospitalizations, and clinical response rates for advanced heart failure patients.

Area of Science:

  • Cardiology
  • Medical Devices
  • Heart Failure Management

Background:

  • Cardiac resynchronization therapy with an implantable defibrillator (CRT-D) is a key treatment for advanced heart failure.
  • The comparative benefit of CRT-D across different established indication classes requires further real-world evaluation.

Purpose of the Study:

  • To assess if the clinical benefits of CRT-D vary based on the specific indication class for device implantation.
  • To compare outcomes such as mortality, heart failure hospitalizations, and patient response rates among different CRT-D indication groups.

Main Methods:

  • A retrospective analysis of 103 patients who received CRT-D between 2006 and 2009.
  • Patients were categorized into three groups based on CRT-D indication: Class IA, Class IIa (with atrial fibrillation), and a non-conventional (NC) group.
  • Outcomes evaluated included all-cause mortality, heart failure hospitalizations, NYHA functional class improvement, and implant-related complications over a 3-year follow-up.

Main Results:

  • No significant differences were observed in all-cause mortality rates (20-23%) among the three groups.
  • Rates of rehospitalization for worsening heart failure (22-33%) and the percentage of clinical responders (78%) were similar across all indication groups.
  • Implant-related complications requiring reintervention (15-25%) were also comparable, despite slight differences in patient demographics and medication use.

Conclusions:

  • The clinical benefit of CRT-D in advanced heart failure patients appears to be consistent across Class IA, IIa, and non-conventional (NC) indications in real-world settings.
  • These findings suggest that CRT-D can be equally effective regardless of the specific guideline indication in appropriately selected patients.
Abstract

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