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Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
Published on: May 30, 2011
Distributions of perfusion and lung water
S U Ekeh1, R Y Chu, V J Ficken
1Department of Radiological Sciences, Veterans Affairs Medical Center, Oklahoma City, OK 73104.
International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
|January 1, 1990
Summary
This study explored using 123I-iodoantipyrine (123I-IAP) and 99mTc-MAA to assess lung injury. 123I-IAP showed total lung mass, while 99mTc-MAA revealed perfusion defects in severe injuries.
Area of Science:
- Nuclear medicine
- Radiopharmacology
- Pulmonary imaging
Background:
- Assessing lung injury requires understanding both perfusion and water content.
- Current methods may not fully capture the spatial distribution of these parameters.
Purpose of the Study:
- To evaluate the feasibility of using 123I-iodoantipyrine (123I-IAP) and 99mTc-labeled macroaggregated albumin (99mTc-MAA) for characterizing lung injury.
- To compare the distribution of lung perfusion and water content using these radiopharmaceuticals.
Main Methods:
- Administered 123I-IAP and 99mTc-MAA to rabbits (n=9), including controls and those with induced lung injuries.
- Utilized a scintillation gamma camera for imaging isolated rabbit lungs.
- Analyzed the distribution patterns of both radiotracers.
Main Results:
- 123I-IAP distribution accurately depicted the entire lung mass in all subjects.
- 99mTc-MAA distribution clearly demonstrated perfusion defects, particularly in cases of severe lung injury.
- The combination of tracers allowed for a comparative analysis of water content and perfusion.
Conclusions:
- 123I-IAP and 99mTc-MAA are feasible tools for assessing lung injury.
- These radiopharmaceuticals can effectively differentiate between overall lung mass and perfusion deficits.
- The study supports the use of these agents for detailed pulmonary injury characterization.
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