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[Daptomycin in outpatient antimicrobial parenteral therapy]
Carlos Cervera1, Carlos A Mestres
1Servicio de Enfermedades Infecciosas, Hospital Clínic de Barcelona-IDIBAPS, Universitat de Barcelona, Barcelona, España. ccervera@clinic.ub.es
Enfermedades Infecciosas Y Microbiologia Clinica
|May 1, 2012
Summary
Daptomycin, a cyclic lipopeptide antibiotic, offers rapid bactericidal effects against Gram-positive bacteria. Its favorable pharmacokinetics and safety profile make it a valuable option for outpatient parenteral antimicrobial therapy (OPAT), particularly for skin and bone infections.
Area of Science:
- Pharmacology
- Infectious Diseases
- Antimicrobial Therapy
Context:
- Daptomycin is a lipopeptide antibiotic effective against Gram-positive bacteria.
- Its pharmacokinetic profile supports once-daily intravenous administration.
- It is recognized for its ease of administration and favorable safety profile.
Purpose:
- To evaluate daptomycin's utility as an outpatient parenteral antimicrobial therapy (OPAT).
- To review evidence supporting daptomycin use in specific Gram-positive bacterial infections.
- To assess daptomycin's success rates in hospitalized and OPAT settings.
Summary:
- Daptomycin exhibits rapid bactericidal activity against Gram-positive pathogens.
- Once-daily IV infusion, including a 2-minute bolus, is the recommended posology.
- Strong evidence supports its use in complicated/uncomplicated skin and soft tissue infections, and osteoarticular infections.
- Case-by-case analysis is recommended for other indications when used as OPAT.
- EUCORE Registry data from Spain show high treatment success rates for daptomycin in both inpatient and OPAT settings.
Impact:
- Daptomycin is a key agent for outpatient parenteral antimicrobial therapy (OPAT).
- It provides an effective and safe treatment option for Gram-positive infections, particularly skin and bone infections.
- Real-world data confirm daptomycin's high success rates in diverse clinical settings, supporting its expanded use in OPAT programs.
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