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Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Connective Tissue Cell Types

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Related Experiment Video

Updated: May 22, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Published on: June 16, 2020

[The German network for systemic sclerosis (DNSS): current data on diagnostics and therapy].

N Hunzelmann1, T Krieg,

  • 1Klinik und Poliklinik für Dermatologie und Venerologie, Klinikum der Universität zu Köln, 50937, Köln, Deutschland. Nico.Hunzelmann@uni-koeln.de

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|May 1, 2012
PubMed
Summary

National cooperation among specialized centers is crucial for rare disease research. The German network for systemic sclerosis (DNSS) patient register, with over 3,100 patients, supports clinical and basic research, fostering international collaboration.

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Area of Science:

  • Rheumatology and rare disease research.
  • Clinical and translational science.

Context:

  • Progress in rare disease understanding requires national collaboration.
  • The German network for systemic sclerosis (DNSS) unites specialized centers.
  • Systemic sclerosis (SSc) is a rare autoimmune disease requiring specialized care.

Purpose:

  • To present the results and significance of the German network for systemic sclerosis (DNSS) patient register.
  • To highlight the role of national cooperation in rare disease research.
  • To showcase the DNSS register as a foundation for clinical and basic studies.

Summary:

  • The DNSS patient register includes over 3,100 systemic sclerosis (SSc) patients.
  • It collects prospective data on diagnostics and therapy.
  • The register is a key resource for national and international research efforts.

Impact:

  • The DNSS register serves as a successful basis for clinical research and basic studies.
  • It facilitates international cooperation in SSc research.
  • The data supports advancements in understanding SSc pathophysiology and treatment.