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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

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Determinants of virological outcomes in kidney transplant recipients treated with maribavir for refractory cytomegalovirus infection.

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Wastewater Surveillance to Estimate and Characterize Hepatitis E Virus Circulation.

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Related Experiment Video

Updated: May 22, 2026

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

Hepatitis E virus: what transplant physicians should know.

N Kamar1, F Legrand-Abravanel, J Izopet

  • 1Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France. kamar.n@chu-toulouse.fr

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|May 3, 2012
PubMed
Summary
This summary is machine-generated.

Hepatitis E virus (HEV) infection is often missed in developed countries, posing risks for transplant patients. This review covers HEV

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Last Updated: May 22, 2026

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
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Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

Area of Science:

  • Hepatology
  • Transplant Infectious Diseases
  • Virology

Background:

  • Hepatitis E virus (HEV) infection is increasingly recognized but underdiagnosed in developed nations.
  • Organ transplant recipients are at higher risk for severe HEV outcomes, including chronic hepatitis and cirrhosis.
  • Extra-hepatic manifestations of HEV, such as neurological and renal complications, are significant concerns in transplant populations.

Purpose of the Study:

  • To provide a comprehensive overview of Hepatitis E virus infection in organ transplant patients.
  • To summarize current knowledge on the prevalence, incidence, and clinical course of HEV in this vulnerable group.
  • To review therapeutic strategies for managing HEV infection post-transplantation.

Main Methods:

  • Systematic literature review of HEV infection in pediatric and adult organ transplant recipients.
  • Analysis of data on HEV prevalence, incidence, and natural history.
  • Evaluation of reported treatment outcomes and therapeutic approaches.

Main Results:

  • HEV infection can lead to chronic hepatitis, cirrhosis, and graft dysfunction in transplant patients.
  • Neurological and kidney complications are notable extra-hepatic manifestations.
  • Treatment outcomes vary, highlighting the need for optimized therapeutic regimens.

Conclusions:

  • HEV infection represents a significant clinical challenge in organ transplant recipients.
  • Early diagnosis and appropriate management are crucial to prevent severe outcomes.
  • Further research is needed to refine treatment protocols and improve patient prognosis.