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Implanted upper airway stimulation device for obstructive sleep apnea.

Paul H Van de Heyning1, M Safwan Badr, Jonathan Z Baskin

  • 1Department of Otorhinolaryngology and Head & Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium. paul.van.de.heyning@telenet.be

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PubMed
Summary
This summary is machine-generated.

Upper Airway Stimulation (UAS) is safe and effective for treating moderate to severe obstructive sleep apnea (OSA) in patients who cannot use CPAP. Responders were identified with specific BMI and AHI criteria.

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Area of Science:

  • Medical Devices
  • Sleep Medicine
  • Otolaryngology

Background:

  • Obstructive sleep apnea (OSA) is a common disorder.
  • Electrical stimulation of the hypoglossal nerve shows promise for OSA treatment.
  • Previous studies demonstrated feasibility, but further investigation is needed.

Purpose of the Study:

  • To evaluate the safety and efficacy of a second-generation Upper Airway Stimulation (UAS) system.
  • To identify predictors of successful therapy for OSA.
  • To assess the UAS system in patients intolerant or unresponsive to CPAP.

Main Methods:

  • Two prospective open studies were conducted.
  • Patients with moderate to severe OSA received UAS implantation.
  • Apnea-hypopnea index (AHI), Epworth Sleepiness Scale (ESS), and Functional Outcomes of Sleep Questionnaire (FOSQ) were measured.

Main Results:

  • In Part 1, responders had BMI ≤32 and AHI ≤50, and no complete concentric palatal collapse.
  • Part 2 patients (n=8) showed significant AHI reduction from 38.9 to 10.0 (P < .01).
  • Both ESS and FOSQ scores improved significantly in all patients.

Conclusions:

  • Upper Airway Stimulation (UAS) is a safe and effective treatment for select OSA patients.
  • UAS offers an alternative for patients who cannot use CPAP.
  • Predictive factors for successful UAS therapy were identified.