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Updated: May 22, 2026

Rapid and Efficient Spatiotemporal Monitoring of Normal and Aberrant Cytosine Methylation within Intact Zebrafish Embryos
Published on: August 18, 2022
Early embryos reprogram DNA methylation in two steps
Abstract:
While DNA cytosine methylation is relatively stable in somatic tissues, it is highly dynamic during preimplantation development. A recent study in Nature by Meissner and colleagues (Smith et al., 2012) now reveals dramatic shifts in DNA methylation during the earliest stages of mouse embryogenesis at genome scale and base resolution.
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