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Trimetazidine in the prevention of contrast induced nephropathy after coronary angiogram

M M Rahman1, S S Haque, B Rokeya

  • 1Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

Mymensingh Medical Journal : MMJ
|May 8, 2012
PubMed

Insights

Trimetazidine effectively prevents contrast-induced nephropathy (CIN) in patients undergoing coronary angiography. This study found a significant reduction in CIN incidence when trimetazidine was administered with saline compared to saline alone.

Area of Science:

  • Cardiology
  • Nephrology
  • Pharmacology

Background:

  • Contrast-induced nephropathy (CIN) is a significant complication following coronary angiography.
  • CIN increases mortality, morbidity, and necessitates interventions like hemodialysis.
  • Patients with elevated serum creatinine are at higher risk for CIN.

Purpose of the Study:

  • To evaluate the efficacy of trimetazidine (TMZ) in preventing CIN.
  • To compare the incidence of CIN in patients receiving trimetazidine plus hydration versus hydration alone.

Main Methods:

  • A prospective randomized controlled trial involving 400 patients undergoing coronary angiography.
  • Patients were divided into two groups: trimetazidine plus saline hydration (n=200) and saline hydration alone (control, n=200).
  • Incidence of CIN was assessed in both groups.

Main Results:

  • The incidence of CIN was significantly lower in the trimetazidine group (4%) compared to the control group (14%) (p<0.05).
  • Trimetazidine administration with saline demonstrated a protective effect against CIN.
  • The findings suggest a beneficial role for trimetazidine in this patient population.

Conclusions:

  • Trimetazidine is effective in preventing contrast-induced nephropathy in patients undergoing coronary angiography.
  • The study supports the use of trimetazidine as an adjunct therapy to hydration for CIN prevention.
  • Further research may explore the long-term benefits and optimal dosing of trimetazidine for CIN prophylaxis.

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