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Related Concept Videos

Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...

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Updated: May 22, 2026

Effects of Mindfulness Training Combined with Tai Chi in Patients with Diabetic Peripheral Neuropathy
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Effects of Mindfulness Training Combined with Tai Chi in Patients with Diabetic Peripheral Neuropathy

Published on: July 14, 2023

Prediabetic neuropathy: does it exist?

Nikolaos Papanas1, Dan Ziegler

  • 1Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Leibniz Center for Diabetes Research, Düsseldorf, Germany. papanasnikos@yahoo.gr

Current Diabetes Reports
|May 8, 2012
PubMed
Summary
This summary is machine-generated.

Prediabetes often causes peripheral neuropathy, affecting small sensory fibers. Managing blood sugar and cardiovascular risks is key for treatment, though long-term outcomes require further study.

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Area of Science:

  • Neurology
  • Endocrinology
  • Diabetology

Background:

  • A significant number of individuals with prediabetes experience peripheral neuropathy or neuropathic pain.
  • Conversely, prediabetes is frequently diagnosed in patients presenting with idiopathic peripheral neuropathy.
  • Neuropathy prevalence in prediabetes falls between that of overt diabetes and normoglycemic individuals.

Purpose of the Study:

  • To summarize the current understanding of prediabetic neuropathy.
  • To discuss the underlying pathogenic mechanisms.
  • To outline current therapeutic strategies and highlight areas for future research.

Main Methods:

  • Literature review and synthesis of existing research on prediabetes and neuropathy.
  • Analysis of epidemiological data regarding neuropathy prevalence.
  • Discussion of implicated etiological factors and treatment approaches.

Main Results:

  • Prediabetic neuropathy is common, often milder than diabetic neuropathy, and primarily impacts small sensory nerve fibers.
  • Key implicated mechanisms include hyperglycemia, microangiopathy, dyslipidemia, and metabolic syndrome.
  • Current management focuses on achieving normoglycemia and addressing cardiovascular risk factors.

Conclusions:

  • Prediabetic neuropathy is a recognized clinical entity linked to metabolic dysfunction.
  • Therapeutic strategies should target glycemic control and cardiovascular health.
  • Further research is essential to determine the long-term efficacy of these interventions.